This presentation will cover the history and political implications of the making of the US-Mexican international for contemporary struggles for labor, immigrant and civil rights across the US-Mexican border. Significant consideration will be given to the tensions and contradictions generated by the uneven interdependence of capitalist development in the borderlands; the long history of solidarity, struggle and resistance against racial and capitalist oppression waged by Native Americans, Mexican Americans and the multinational working class in the region; and, the potential of these developments for the political challenges posed by transnational capitalism and globalization in Mexico and the United States.